Nurses are the backbone of any healthcare system. Recently, the healthcare systems have witnessed various challenges of pandemics, nursing shortage, limited resources, wars, an increase in the burden of chronic illnesses and psychiatric disorders, and an increase in senior citizens. Nurses, in all practice settings, devote their time to helping people in need to cultivate hope for the survival of humanity. Hence the idea of the 2nd International Nursing Conference came to existence from various discussions between the Faculty of Nursing, at Zarqa University, jointly with the Jordanian Nursing Council and other Nursing Faculties worldwide to shed light on the situation of the nursing profession in present times. Holding this conference is an important station for discussion and exchanging views and experiences on the contemporary issues related to various aspects of the nursing profession in light of the challenges facing the health systems worldwide.